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Importance of group X–secreted phospholipase A 2 in allergen-induced airway inflammation and remodeling in a mouse asthma modelстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 декабря 2016 г.
- Авторы: Henderson William R., Chi Emil Y., Bollinger James G., Tien Ying-tzang, Xin Ye, Castelli Luca, Rubtsov Yuri P., Singer Alan G., Chiang Gertrude K.S., Nevalainen Timo
- Журнал: Journal of Experimental Medicine
- Том: 204
- Номер: 4
- Год издания: 2007
- Издательство: Rockefeller University Press
- Местоположение издательства: United States
- Первая страница: 865
- Последняя страница: 877
- DOI: 10.1084/jem.20070029
- Аннотация: Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A2s (PLA2s), most notably cytosolic PLA2-α. 10 secreted PLA2s (sPLA2s) have also been identified, but their function in eicosanoid generation is poorly understood. We investigated the role of group X sPLA2 (sPLA2-X), the sPLA2 with the highest in vitro cellular phospholipolysis activity, in acute and chronic mouse asthma models in vivo. The lungs of sPLA2-X−/− mice, compared with those of sPLA2-X+/+ littermates, had significant reduction in ovalbumin-induced infiltration by CD4+ and CD8+ T cells and eosinophils, goblet cell metaplasia, smooth muscle cell layer thickening, subepithelial fibrosis, and levels of T helper type 2 cell cytokines and eicosanoids. These data direct attention to sPLA2-X as a novel therapeutic target for asthma.
- Добавил в систему: Рубцов Юрий Петрович