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Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumorsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
- Авторы: Gershtein E.S., Isaeva E.R., Kushlinsky D.N., Korotkova E.A., Ermilova V.D., Laktionov K.P., Adamyan L.V.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 160
- Номер: 6
- Год издания: 2016
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 814
- Последняя страница: 816
- DOI: 10.1007/s10517-016-3317-2
- Аннотация: IGF-1, IGF-2, and IGFBP-1,2,3 were assayed in blood serum of patients with malignant ovarian tumors (n=44), borderline ovarian tumors (n=11), and benign ovarian tumors (n=12) as well as in healthy women (n=33). In blood serum of patients with malignant ovarian tumors, the level of IGF-1 was lower and IGFBP-1 was higher than in other groups. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. There was no correlation between most examined parameters and the clinical and morphological peculiarities of ovarian tumors. The study revealed IGF/IGFBP imbalance in patients with malignant ovarian tumor and showed that IGFBP-2 proved to be a potential diagnostic serological marker w with 90% sensitivity and 90% specificity. В© 2016, Springer Science+Business Media New York.
- Добавил в систему: Герштейн Елена Сергеевна