Temperature-induced unloading of liposomes bound to microgelsстатья
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Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
Аннотация:Bilayer lipid vesicles (liposomes) composed of zwitter-ionic (electroneutral) egg yolk lecithinand anionic phosphatidylserine were loaded with a water-soluble antitumor antibiotic Dox andelectrostatically adsorbed onto the surface of thermo-sensitive microgels synthesized from 3-(N,N-dimethylamino)propylmethacrylamide, N,N-methylenebisacrylamide and 2,2′-azobis(2-methylpropionamidine) dihydrochloride. The resulting saturated microgel-liposomes complexwith ultimately adsorbed 40 liposomes retains encapsulated drug in water solution at 25 °C. Anincrease in temperature induces a collapse of the microgel core and squeezing of the liposomeshell, followed by liposome disruption and a release of encapsulated Dox. An intensive Doxleakage begins when temperature reaches 39 °C; a maximum amount of Dox is released within 5minutes after starting the temperature trigger. The results are of importance for constricting ofthermo-sensitive drug carries and developing protocols for the most productive drug release.