Аннотация:Assessment of the allogenic proliferative response of different subpopulations (CD4+, CD8+, CD4-CD8-) of liver T-lymphocytes to class I and II mutant MHC molecules showed that, like peripheral T-lymphocytes, liver T-lymphocytes CD4+ recognized class II but not class I, whereas CD8+ recognized class I but not II. Monoclonal antibodies against CD4 and CD8 coreceptors selectively inhibited the response of liver T-lymphocytes to mutant MHC molecules of class II and I, respectively. Spleen lymphocytes CD4-CD8- did not proliferate in their response to alloantigens. On the contrary, removal of CD4+ and CD8+ T-cells from the liver lymphocyte population did not completely abolish the response. Thus, the primary proliferative allogenic response of liver lymphocytes was in agreement with the classical scheme of MHC-restricted recognition, and thymus should be considered the most probable source of alloreactive liver T-lymphocytes.