Fluorescence of radiation-induced tissue damageстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 октября 2021 г.
Аннотация:Purpose: The aim of this study was evaluating changes in the photosensitizer fluorescence in vivo inthe radiation-induced damage area in comparison of intact areas with a simultaneous assessment ofchanges both in blood parameters and in histological data.Materials and methods: The study was conducted in white outbred SHK mice (n¼21). Their right hindlimbswere irradiated with a dose of 25 Gy after the intraperitoneal injections of photosensitizer‘Photosens’. Fluorescence intensity was traced in vivo by a laser diagnostic system for seven weeks.Simultaneously, histological examination of the damaged areas and blood tests were performed.Results: An increased intensity of the laser-induced fluorescence of the photosensitizer ‘Photosens’ inthe damaged areas, compared to the intact symmetrical ones was observed. Laboratory blood testsand histological examination showed changes that may indicate the occurrence of inflammation.Conclusion: Enhanced intensity of the exogenous fluorescence of the photosensitizer in the radiationinducedinflammation of noncancerous tissues was observed. The obtained results may potentiallyaffect an interpretation of the results of intraoperative tumors navigation that have been previouslyirradiated and can be used for selection of an individualized dose fractionation algorithm in radiology.