Comparative study of macrocyclic and acyclic picolinate derivatives for chelation of copper cations

Egorova, B.V.; Kalmykova, T.P.; Zubenko, A.D.; Shchukina, A.A.; Karnoukhova, V.A.; Likhosherstova, D.V.; Priselkova, A.B.; Fedorov, Y.V.; Fedorova, O.A.; Kalmykov, S.N.

Авторы: Egorova Bayirta Vladimirovna, Kalmykova Taisia P., Zubenko Anastasia D., Shchukina Anna A., Karnoukhova Valentina A., Likhosherstova Daria V., Priselkova Anna B., Fedorov Yuri V., Fedorova Olga A., Kalmykov Stepan N.
Журнал: European Journal of Inorganic Chemistry
Год издания: 2021
Издательство: John Wiley & Sons Ltd.
Местоположение издательства: United Kingdom
DOI: 10.1002/ejic.202100751
Аннотация: In this work we presented a synthesis and investigation ofrelative acyclic and macrocyclic polyamines with picolinate pendantarms as potential chelators for copper radiopharmaceuticals. It hasbeen shown that linear chelators lacking bisamide moiety are muchmore basic and form complexes with higher stability constantscompared to macrocyclic ones. Both types of ligands possess manydonor sites due to picolinate groups enabling formation of polynuclearcomplexes in the solution and solid state. According to crystalstructures metal cations coordinates with studied ligands through thebinding with aminogroups and picolinates donor atoms, while terminalaminogroups of acyclic ligands do not take part in the complexformation. Tripicolinate azacrown ligand coordinates cations outsidethe macrocyclic cavity in non-equivalent positions. However this outcagelocation as well as a moderate logK value do not induce fastrelease of cation from this complex in the challenging medium ofserum proteins.
Добавил в систему: Федоров Юрий Викторович

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Comparative study of macrocyclic and acyclic picolinate derivatives for chelation of copper cationsстатья

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