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Evaluation of the Effect of Cell Parameters on the Number of Microtubule Merotelic Attachments in Metaphase Using a Three-Dimensional Computer Modelстатья
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
- Авторы: Krivov Maxim A., Ataullakhanov Fazoil I., Ivanov Pavel S.
- Журнал: Advances in Intelligent Systems and Computing
- Том: 1240
- Год издания: 2020
- Первая страница: 144
- Последняя страница: 154
- DOI: 10.1007/978-3-030-54568-0_15
- Аннотация: Even chromosome segregation between daughter cells during mitosis is crucial for genome integrity and is mostly regulated by proper attachments of spindle microtubules (MTs) to kinetochores. Abnormalities in this process can lead to chromosome mis-segregation and potentially result in severe developmental disorders, including aneuploidy and cancer. Merotelic attachments when tubulin MTs captured by kinetochore of one chromatid originate from both spindle poles are considered as one of the key molecular processes that cause such abnormalities. Here we present the first comprehensive three-dimensional model of metaphase, the key stage of mitosis in the context of proper chromosome segregation, and the results of its application to supercomputer simulation of kinetochore-MT attachments in metaphase. It appears that large values of the kinetochore crown angle lead to the preservation of merotelic attachments while the size of the cell and the probability of MT detachments affect only the rate of their suppression but do not interfere with the process of suppression itself. It has been demonstrated that the structure and the set of parameters of the model of mitosis have a severe impact on the results of simulations. We also compare the results of supercomputer 3D modeling of mitosis with outcomes of existing two-dimensional models.
- Добавил в систему: Иванов Павел Сергеевич