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The effects of KKRRPGP (Lys-Lys-Arg-Arg-Pro-Gly-Pro) and KRRKPGP (Lys-Arg-Arg-Lys-Pro-Gly-Pro) peptides on hemostasis parameters, lipid profile, blood glucosae level, and body weight changes in rats with metabolic syndrome and endothelial dysfunctionстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
- Авторы: Myasoedov N.F., Lyapina L.A., Obergan T.Yu, Grigor'eva M.E., Shubina T.A., Andreeva L.A.
- Журнал: Moscow University Biological Sciences Bulletin
- Том: 76
- Номер: 1
- Год издания: 2021
- Издательство: Allerton Press
- Местоположение издательства: New York, N.Y., United States
- Первая страница: 7
- Последняя страница: 13
- DOI: 10.3103/S009639252101003X
- Аннотация: Intranasal administration of lysine- and arginine-containing peptides Lys-Lys-Arg-Arg-Pro-Gly-Pro and Lys-Lys-Arg-Arg-Pro-Gly-Pro was performed daily at a single dose of 0.1 mg/kg for 7 days on rats with experimental metabolic syndrome end endothelial dysfunction. It was found that these peptides had anticlotting, hypoglycemic, and lipid-lowering effects and reduced body weight gain in experimental rats.They affected both primary (vascular-platelet) hemostasis, decreasing platelet aggregation, and increasing anticoagulant, fibrin-depolymerizing, and enzymatic fibrinolytic activities, and reducing the concentration of fibrinogen in it. At the same time, the studied peptides diminished the content of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, whale increasing the concentracion of high-densuty lipoprotein cholesterol. The maximum effects were provided by the Lys-Arg-Arg-Lys-Pro-Gly-Pro peptide, which may be associated with its structural features.
- Добавил в систему: Оберган Тамара Юрьевна