Аннотация:Long non-coding RNAs (lncRNAs) can be dysregulated in many diseases including various cancers. They could serve as perspective biomarkers for primary diagnostics of malignancies, discrimination of different tumors or as prognostic criteria for patients. In our previous work we discovered a novel lncRNA HELIS (aka “healthy liver specific”) that is significantly down-regulated in hepatocellular carcinoma (HCC), but is not expressed in liver cholangiocarcinoma (CCA) and hepatoblastoma (HBL) neither in other normal nor malignant human tissues including pancreas. During our search for additional biomarkers, we have found a novel transcript that we have called CHOL. We showed that its expression is upregulated mainly in CCA samples (but not in HCC) as well as in case of pancreatic duct adenocarcinoma (PDAC) in comparison to adjacent normal tissues.
