Complete Genome Sequence, Molecular Characterization and Phylogenetic Relationships of a Novel Tern Atadenovirus

Matsvay, A.; Dyachkova, M.; Mikhaylov, I.; Kiselev, D.; Say, A.; Burskaia, V.; Artyushin, I.; Khafizov, K.; Shipulin, G.

Авторы: Matsvay Alina, Dyachkova Marina, Mikhaylov Ivan, Kiselev Daniil, Say Anna, Burskaia Valentina, Artyushin Ilya, Khafizov Kamil, Shipulin German
Журнал: Microorganisms
Том: 10
Номер: 1
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 31
DOI: 10.3390/microorganisms10010031
Аннотация: Abstract: Discovery and study of viruses carried by migratory birds are tasks of high importance due to the host’s ability to spread infectious diseases over signiﬁcant distances. With this paper, we present and characterize the ﬁrst complete genome sequence of atadenovirus from a tern bird (common tern, Sterna hirundo) preliminarily named tern atadenovirus 1 (TeAdV-1). TeAdV-1 genomeis a linear double-stranded DNA molecule, 31,334 base pairs which contain 30 methionine-initiated open reading frames with gene structure typical for Atadenovirus genus, and the shortest known inverted terminal repeats (ITRs) within the Atadenovirus genus consisted of 25 bases. The nucleotide composition of the genome is characterized by a low G+C content (33.86%), which is the most AT-rich genome of known avian adenoviruses within Atadenovirus genus. The nucleotide sequence of the TeAdV-1 genome shows high divergence compared to known representatives of the Atadenovirus genus with the highest similarity to the duck atadenovirus 1 (53.7%). Phylogenetic analysis of the protein sequences of core genes conﬁrms the taxonomic afﬁliation of the new representative to thegenus Atadenovirus with the degree of divergence from the known representatives exceeding the interspecies distance within the genus. Thereby we proposed a novel TeAdV-1 to be considered as a separate species.
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Complete Genome Sequence, Molecular Characterization and Phylogenetic Relationships of a Novel Tern Atadenovirusстатья Исследовательская статья

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