Synthesis and molecular structure of 4-{[6-((2SR,4SR)-4-acetyl- 4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin- 4-yl]oxy}-3,5-dimethylbenzonitrile and 4-[(6-{(2SR,4SR)-4-acetyl- 1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}- 2-(4-cyanophenoxyстатья
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Дата последнего поиска статьи во внешних источниках: 3 февраля 2022 г.
Аннотация:A novel diarylpyrimidine derivative, 4-{[6-((2SR,4SR)-4-acetyl-4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile containing a pyrrolidine moiety at position 6 of the pyrimidine ring was obtained as a result of the tandem aza-Cope/Mannich reaction between 4-{[2-(4-cyanophenoxy)-6-formylpyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile and 1-amino-2,3-dimethylbut-3-en-2-ol in methylene chloride in the presence of 10-camphorsulfonic acid. The structure of the product of its reactionwith 4-bromobenzenesulfonyl chloride, 4-[(6-{(2SR,4SR)-4-acetyl-1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}-2-(4-cyanophenoxy)pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile, was investigated by X-ray structural analysis.