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Oligomers Are Promising Targets for Drug Development in the Treatment of Proteinopathiesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
- Автор: Galzitskaya Oxana V.
- Журнал: Frontiers in Molecular Neuroscience
- Том: 12
- Год издания: 2020
- Издательство: Frontiers Research Foundation
- Местоположение издательства: Switzerland
- Номер статьи: 319
- DOI: 10.3389/fnmol.2019.00319
- Аннотация: Currently, there is no effective treatment of proteinopathies, as well as their diagnosis in the early stages of the disease until the first clinical symptoms appear. The proposed model of fibrillation of the A beta peptide and its fragments not only describes molecular rearrangements, but also offers models of processes that occur during the formation of amyloid aggregates. Since this model is also characteristic of other proteins and peptides, a new potential target for drug development in the treatment of Alzheimer's disease (AD) and other proteinopathies is proposed on the basis of this model. In our opinion, it is oligomers that are promising targets for innovative developments in the treatment of these diseases.
- Добавил в систему: Галзитская Оксана Валериановна