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Trajectories of the movement of cytochrome c molecules nearby bc1 complex in mitochondrial crista – Brownian dynamics modelтезисы доклада
- Авторы: Abaturova A.M., Riznichenko G.Yu
- Сборник: International Congress devoted to the Memory of the Founders of Biophysics Department of Physics Faculty of Lomonosov Moscow State University – professor L.A. Blumenfeld and professor S.E. Shnoll
- Тезисы
- Год издания: 2021
- Издательство: Globustar Formaat
- Местоположение издательства: Tallinn, Estonia
- Первая страница: 6
- Последняя страница: 6
- DOI: 10.52455/sbpr.02.202102
- Аннотация: Cytochrome C (cyC) transfers electrons in the mitochondrial respiratory chain between cytochrome bc1 (BC1) and IV membrane complexes. Using the ProKSim program [1], we constructed a model of the Brownian dynamics of diffusion of oxidized cyC (PDB ID 6FF5) in crista regions 300x300x120 Å containing reduced BC1 dimers (PDB ID 1BGY). The diffusion of cytC was simulated for 50 μs. The electrostatic forces of attraction between cyC and BC1 did not prevent cyC from escaping from BC1 but ensured frequent entry of cyC into electrostatically advantageous regions near BC1. Furthermore, it was found that cytC often passes along BC1via the path connecting the sites of its binding with BC1 and with the IV respiratory complex in the respirasome (PDB ID 5GPN), determined by cryoelectron microscopy. Such a trajectory provides a faster electronic transport of cytC between BC1 and IV respiratory complex.
- Добавил в систему: Абатурова Анна Михайловна