Amorphous and crystalline cerium phosphates: biocompatible ROS-scavenging sunscreensстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 11 мая 2022 г.
Аннотация:This paper reports on a comprehensive study of the UV-shielding properties (namely, the sun protection factor and the factor of protection against UV-A radiation) and cytotoxicity (including photocytotoxicity) of amorphous and crystalline cerium(IV) phosphates. It has been shown that cerium(IV) phosphate NH4Ce2(PO4)3 is characterised by UV-shielding properties that are comparable to nanocrystalline TiO2 and CeO2. Moreover, cerium(IV) phosphates do not show toxicity towards cell cultures of NCTC L929 line mouse fibroblasts and human mesenchymal stem cells, in a wide range of concentrations, and even enhance the proliferative activity of the latter. In a model study of the photoprotective properties of cerium(IV) phosphates on human mesenchymal stem cells, the pronounced protective effect of NH4Ce2(PO4)3 was observed, which was comparable to the shielding action of nanocrystalline CeO2. The results show the tetravalent cerium phosphates can be considered as promising UV-filters for sunscreen applications.