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CT-Perfusion in Differential Diagnostics of Hepatic Tumors. Medical Visualization. 2015;(5):18-31статья
Статья опубликована в журнале из списка Web of Science и/или Scopus
- Авторы: Dolgushin M.B., Tulin P.E., Odzharova A.A., Mescheryakova N.A., Nevzorov D.I., Menkov M.A., Patyutko Yu I., Dolgushin B.I.
- Журнал: Медицинская визуализация
- Номер: 5
- Год издания: 2015
- Аннотация: Aim: to evaluate possibilities of CT-perfusion methods for differential diagnosis of the liver tumors. Materials and methods. The study included results of CT-perfusion of the liver in 50 patients. In subsequent histological examination of the material in 45 patients different types of cancer were identified (in 42patients:metastasis of extra hepatic tumors - 22, hepatocellular carcinoma - 12, intrahepatic form of cholangiocellular cancer - 6), or benign tumors (in 3 patients: focal nodular hyperplasia - 1, hepatocellular adenoma - 1, hemangioma - 1). Liver disease was not confirmed in 5 patients. CT perfusion was performed on Siemens Biographm CT (KVp - 100, mAs - 150, the number of “Omnipak” 300 mg/ml by intravenous injection - 50 ml, the rate of administration of contrast agent - 2.5-4 ml/s, the time from the introduction of a contrast agent till the scanning - 8 seconds, total scan time - 45 seconds). After obtaining a series of images of CT perfusion the data processing was carried out at the Siemens Multy Modality Workplace workstation in off-line mode. Quantitative analysis was performed on the following parameters: BV (blood volume), BF (blood flow), ALP (arterial liver perfusion), PVP (portal liver perfusion), HPI (hepatic perfusion index) and PMB (permeability). Results. Average values of perfusion in the liver parenchyma in the group of patients with “conventional norm” were the following: BF - 29.97 ml / 100ml/min, BV - 13.16 ml / 100 ml, ALP - 20.69 ml / 100 ml/min, PVP - 91.33 ml / 100 ml/min, PMB - 44.88 ml / 100 ml/min and HPI - 20.90% (p ≤ 0.05), in the group of patients with hepatocellular carcinoma: BF - 53.71 ml / 100 ml/min, BV - 12.42 ml/100 ml, ALP - 49.13 ml / 100 ml/min, PVP - 11.89 ml / 100 ml/min, PMB - 31.35 ml / 100 ml/min and HPI - 81.20% (p ≤ 0.05), in the solid component of cholangiocellular cancer (CROMAC): BF - 44.94 ml / 100 ml/min, BV - 14.89 ml / 100 ml, ALP - 49.58 ml / 100 ml/min, PVP - 29.10 ml / 100 ml/min, PMB - 34.90 ml / 100 ml/min and HPI - 69.83%, in the solid components of metastasis: BF - 25.62 ml / 100 ml/min, BV - 17 11 ml / 100 ml, ALP - 30.61 ml / 100 ml/min, PVP - 20.87 ml / 100 ml/min, PMB - 21.12 ml / 100 ml/min and HPI - 62.67%. Conclusions. CT-perfusion method allows to assess quantitative the hemodynamic properties of tissues in the different liver tumors that can be used in a primary differential diagnostics as well as to evaluate the effectiveness of the treatment.
- Добавил в систему: Тулин Павел Евгеньевич