Problems of Red Blood Cell Aggregation and Deformation Assessed by Laser Tweezers, Diffuse Light Scattering and Laser Diffractometry

Авторы: Semenov Alexey, Lugovtsov Andrei, Ermolinskiy Petr, Lee Kisung, Priezzhev Alexander
Журнал: Photonics
Том: 9
Номер: 4
Год издания: 2022
Первая страница: 238-1
Последняя страница: 238-17
Номер статьи: 9040238
DOI: 10.3390/photonics9040238
Аннотация: This study aims to highlight the problems with implementing optical techniques (laser tweezers, diffuse light scattering and laser diffractometry) in clinical hemorheological practice. We provide the feasibility of these techniques to assess microrheological effects of various molecular mechanisms affecting RBC aggregation and deformability. In particular, we show that they allow assessment of changes in RBC aggregation in whole blood samples both on the level of single cells and on the level of large ensembles of cells. Application of these methods allows for studying the mechanisms of RBC aggregation because they are sensitive to changes in the medium which surrounds the RBC (i.e., blood plasma, serum or model solutions of blood plasma proteins) and to changes in the cellular properties of RBCs (i.e., effects on the cell membrane due to glycoprotein inhibition)
Добавил в систему: Луговцов Андрей Егорович

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