Pallidal neuron activity determines responsiveness to deep brain stimulation in cervical dystonia

Sedov, A.; Popov, V.; Gamaleya, A.; Semenova, U.; Tomskiy, A.; Jinnah, H.A.; Shaikh, A.G.

Авторы: Sedov A., Popov V., Gamaleya A., Semenova U., Tomskiy A., Jinnah H.A., Shaikh A.G.
Журнал: Clinical Neurophysiology
Том: 132
Номер: 12
Год издания: 2021
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 3190
Последняя страница: 3196
DOI: 10.1016/j.clinph.2021.07.032
Аннотация: Objective: In patients with cervical dystonia we sought for the differences in neuronal behavior of pallidal regions where deep brain stimulation resulted in favorable therapeutic response compared to those where the response was absent.Methods: We compared single-unit activity of 564 neurons recorded from deep brain stimulation sensitive and non-sensitive regions in 17 cervical dystonia patients.Results: Globus pallidus internus regions responsive to the deep brain stimulation had lower firing rates and bursting compared to non-responsive areas. The differences were robust in locations where neuronal responses correlated with neck movements. Per the effects of deep brain stimulation, the pallidal regions were classified in weak, intermediate, and excellent responsive. Pallidal regions with weak response to deep brain stimulation had fewer burst neurons and higher firing rate compared to neurons in areas with excellent response. The burst index was significantly decreased in excellent response regions. There was a significant decrease in the alpha band oscillation score but a substantial increase in the gamma band in excellent response neurons.Conclusion: The pallidal region that would be responsive to deep brain stimulation has distinct physiology compared to the non-responsive region.Significance: These results provide novel insights into globus pallidus interna neurons' physiology in cervical dystonia.Keywords: Burst neuron; Cervical dystonia; Deep brain stimulation; Globus pallidum; Single-unit physiology.
Добавил в систему: Гамалея Анна Александровна

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Pallidal neuron activity determines responsiveness to deep brain stimulation in cervical dystoniaстатья

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