Аннотация:Fruits as nutritious meals are enriched with bioactive compounds, antioxidants, vitamins, and micronutrients, constituting a significant portion of the human diet and agriculture production. Nevertheless, the horticultural trade faces many challenges, such as biotic and abiotic stresses, including plant diseases, pests, drought, heat, and salinity. Ecological stresses directly lead to physiological and biochemical alterations such as osmotic and oxidative stress, insufficient nutrients uptake, and decreased photosynthesis in plants; therefore growers utilize chemical pesticides and fertilizers to prevent fruit loss, leading to adverse impacts on environmental health. On the other hand, microbial inoculants and biofertilizers are practical solutions that have been shown to enhance crop yield during stressful conditions. Plant growth–promoting rhizobacteria and endophytic microbes can overcome the stresses by employing mechanisms such as changes in root system architecture, induction of systematic resistance, and regulation of expression of stress-responsive genes. Microbial strains were also advantageous agents in shielding postharvest fruits against various pathogens. The present chapter aims to review studies about the performance of microbial inoculants in fruits during various biotic and abiotic stresses. Future studies should be focused on enhancing the efficiency of microbial strains by addressing the crucial role of microbial inoculants in improving crop yield and combating the negative consequences of environmental stresses.