ITAS: Integrated Transcript Annotation for Small RNA

Stupnikov, A.; Bezuglov, V.; Skakov, I.; Shtratnikova, V.; Pilsner, J.R.; Suvorov, A.; Sergeyev, O.

Авторы: Stupnikov Alexey, Bezuglov Vitaly, Skakov Ivan, Shtratnikova Victoria, Pilsner J.Richard, Suvorov Alexander, Sergeyev Oleg
Журнал: Non-Coding RNA
Том: 8
Номер: 3
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 30
DOI: 10.3390/ncrna8030030
Аннотация: Transcriptomics analysis of various small RNA (sRNA) biotypes is a new and rapidly developing field. Annotations for microRNAs, tRNAs, piRNAs and rRNAs contain information on transcript sequences and loci that is vital for downstream analyses. Several databases have been established to provide this type of data for specific RNA biotypes. However, these sources often contain data in different formats, which makes the bulk analysis of several sRNA biotypes in a single pipeline challenging. Information on some transcripts may be incomplete or conflicting with other entries. To overcome these challenges, we introduce ITAS, or Integrated Transcript Annotation for Small RNA, a filtered, corrected and integrated transcript annotation containing information on several types of small RNAs, including tsRNAs, for several species (Homo sapiens, Rattus norvegicus, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans). ITAS is presented in a format applicable for the vast majority of bioinformatic transcriptomics analysis, and it was tested in several case studies for human-derived data against existing alternative databases.
Добавил в систему: Безуглов Виталий Сергеевич

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ITAS: Integrated Transcript Annotation for Small RNAстатья

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