Способность малых интерферирующих РНК-олигонуклеотидов снижать инфекционную активность вируса гепатита C в культурах клетокстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 июня 2022 г.
Аннотация:The use of the RNA interference technique yielded data on the antiviral activity of small interfering RNA (siRNA) oligonucleotides against hepatitis C virus (HCV) infection in the pig embryo kidney (SPEV) cell cultures. The RNA interference technique is based on the specific recognition of the mRNA target by using the specially designed siRNA (19-22 bp) oligonucleotides. In particular, it was shown that siRNA added to the monolayer of HCV-infected SPEV cells resulted in the protection of the infected cells against the cytopathogenic activity of the virus. The results were confirmed in the experiments that demonstrated the ability of RNA oligonucleotides to reduce the production of infectious (cytopathogenic) HCV by infected SPEV cells in early-stage infection.удк 615.281.8.03.578.891].012.6.076.7