NEW NANOSIZED SYSTEMS WITH ANTITUMOR ACTIVITY BASED ON THE PT(IV) COMPLEXES WITH NICOTINAMIDE LIGANDS AND AMPHIPHILIC COPOLYMERS OF N-VINYLPYRROLIDONE AND (DI)METHACRYLATE

Kurmaz, S.V.; Konev, D.V.; Kurmaz, V.A.; Kozub, G.I.; Ignat'ev, V.M.; Emel'yanova, N.S.; Balakina, A.A.; Terentyev, A.A.

Авторы: Kurmaz S.V., Konev D.V., Kurmaz V.A., Kozub G.I., Ignat'ev V.M., Emel'yanova N.S., Balakina A.A., Terentyev A.A.
Журнал: ИНЭОС OPEN
Том: 4
Номер: 5
Год издания: 2021
Издательство: Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А. Н. Несмеянова Российской академии наук
Местоположение издательства: Москва
Первая страница: 195
Последняя страница: 201
DOI: 10.32931/io2123a
Аннотация: The nanosized systems involving Pt(IV) complexes with antitumor activity are obtained by their solubilization via amphiphilic copolymers of N-vinylpyrrolidone and (di)methacrylates synthesized by the radical copolymerization in toluene without any polymer chain growth terminating agents. The resulting systems are investigated by a complex of physico-chemical methods (IR spectroscopy, DLS, TEM, cyclic and square-wave voltammetry) and quantum chemical simulation. The Pt(IV) complexes are shown to have cytotoxic effects on A-172 tumor cells and the corresponding cytotoxicity indices (IC50) are determined. The amphiphilic copolymers under consideration are promising modern platforms and delivery vehicles for biologically active compounds.
Добавил в систему: Курмаз Владимир Александрович

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NEW NANOSIZED SYSTEMS WITH ANTITUMOR ACTIVITY BASED ON THE PT(IV) COMPLEXES WITH NICOTINAMIDE LIGANDS AND AMPHIPHILIC COPOLYMERS OF N-VINYLPYRROLIDONE AND (DI)METHACRYLATEстатья

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