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Imaging of homeostatic, neoplastic, and injured tissues by HA-base probesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Veiseh M., Breadner D., Ma J., Akentieva N.P., Savani R.C., Harrison R., Mikilus D., Collis L., Gustafson S., Lee T.Y., Koropatnick J., Luyt L.G., Bissell M.J., Turley E.
- Журнал: Biomacromolecules
- Том: 13
- Номер: 1
- Год издания: 2012
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 12
- Последняя страница: 22
- Аннотация: An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during theremodeling of tissue microenvironments following injury and during disease processes such ascancer. We hypothesized that multimodality HA-based probes selectively target and detectablyaccumulate at sites of high HA metabolism, thus providing a flexible imaging strategy formonitoring disease and repair processes. Kinetic analyses confirmed favorable available serumlevels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear(technetium-HA, 99mTc-HA, and iodine-HA, 125I-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (99mTc-HA), breastcancer cells/xenografts (TR-HA, Gd-HA), and vascular injury (125I-HA, TR-HA). Targeting ofHA probes to these sites appeared to result from selective HA receptor-dependent localization.Our results suggest that HA-based probes, which do not require polysaccharide backbonemodification to achieve favorable half-life and distribution, can detect elevated HA metabolism inhomeostatic, injured, and diseased tissues.
- Добавил в систему: Акентьева Наталья Павловна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Veiseh_and_Akentieva.pdf | 2,7 МБ | 1 июня 2022 [Akentieva] |