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Pregnancy outcomes in pregnant women with different types of glomerulonephritisстатья Электронная публикация Тезисы
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kirsanova Tatiana, Rumiantseva Elizaveta, Ivanova Olga, Vinogradova Maria, Fedorova Tatiana, Balakireva Alina
- Журнал: Nephrology Dialysis Transplantation
- Том: 35
- Номер: Suppl 3
- Год издания: 2020
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Номер статьи: gfaa142.P0483
- DOI: 10.1093/ndt/gfaa142.p0483
- Аннотация: Background and AimsConnection between active glomerulonephritis (GN) and adverse pregnancy outcomes is well known. The analysis of pregnancy outcomes for patients with different types of GN in remission has not been performed.Aim: to investigate pregnancy outcomes in women with inactive lupus nephritis (LN), IgA nephropathy and unspecified types of GN.MethodA retrospective single-center cohort study 11/2014 – 12/2019: 91 patients with GN in remission > 20 weeks of gestation. Proved IgA-nephropathy was observed in 14 patients, proved LN in 26 patients, 4 patients had proved antiphospholipid syndrome secondary to LN and 51 patients had unspecified types of GN (without morphological confirmation). Morphological class of LN was confirmed in 9 patients: 3rd in 5, 4th in 2, 5th in 2 patients. Renal function at conception, during pregnancy and after delivery, pregnancy outcomes, clinical and laboratory parameters were collected. PE was diagnosed by the 2008 WHO criteria. The sFlt-1/PlGF ratio was used as the main differential marker to exclude GN exacerbation in cases of increased proteinuria.ResultsRate of preterm birth was significantly higher in patients with LN compared to patients with IgA nephropathy (p = 0.002) and patients with unspecified GN (p < 0.0001), and also in patients with APS plus LN compared to patients with unspecified GN (p < 0.0001) and IgA nephropathy (p = 0.004). PE was observed in 24 patients (25%), type of GN did not affect the incidence of PE. Week of delivery was significantly lower in women with LN compared to IgA-nephropathy (p = 0.013) and unspecified types of GN (p = 0.001) and almost significantly lower in patients with LN plus APS than patients with IgA-nephropathy (p = 0.051) and unspecified types of GN (p = 0.06). Birth weight was significantly higher in babies born to women with unspecified types of GN compared to women with LN (p = 0.018) and LN plus APS (p = 0.047).ConclusionAlthough the rate of PE is similar, the risks of preterm births are high in LN and LN plus APS patients. In this study, laboratory parameters and medical therapy did not significantly affect the pregnancy outcomes.
- Добавил в систему: Балакирева Алина Игоревна