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In search of bladder cancer markers: are human papillomaviruses and cellular INK4a expression associated?статья
- Авторы: Volgareva G.M., Zavalishina LE Golovina DA, Andreeva YY, Cheban NL, Ermilova V.D., Petrov A.N., Bateva M.V., Matveev V.B., Shtil A.A., Frank G.A.
- Сборник: Tumor Markers Research Perspectives (G.A. Sinise, ed.)
- Год издания: 2007
- Издательство: Nova Science Publishers, Inc.
- Местоположение издательства: United States
- Первая страница: 135
- Последняя страница: 143
- Аннотация: Bladder tumors including papilloma-like malformations are widely spread types of human oncopathology. Early diagnostics at the stages when treatment may be effective is carried out in a low percent of bladder cancer (BC) cases. A number of BC risk factors is known, such as cigarette smoking, environmental (largely industrial) pollutants, schistosomiasis, and treatment with alkylating chemotherapeutics. Several genetic abnormalities are associated with BC. The Ras family genes mutations occur in less than half of primary BC; the significance of these mutations as diagnostic markers remains unclear. A variety of mutations of the tumor suppressors Rb and p53 has been found in BC; furthermore, simultaneous inactivation of tumor suppressors INK4a (that codes for p16INK4 protein) and ARF has been reported. Thus, the need for further search for molecular markers of BC is evident.The hypothesis that the human papillomaviruses (HPV) participate in bladder carcinogenesis is not novel; however, more detailed analysis is warranted given that different research groups obtained contradicting results. If HPV does play a role in BC etiology, the expression profiles of certain host cell genes may become the diagnostic markers, as it is the case in cervical cancer
- Добавил в систему: Волгарева Галина Михайловна