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The study of hypotensive action of dinitrosyl-iron complex with glutathione containing drug oxacom in healthy volunteersстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
- Авторы: Chazov EI, Rodnenkov OV, Zorin AV, Lakomkin VL, Gramovich VV, Vyborov ON, Dragnev AG, Timoshin AA, Buriachkovskaia LI, Abramov AA, Dobrovol'skiĭ AB, Maksimov GV, Masenko VP, Arzamastsev EV, Kapel'ko VI, Vanin AF
- Журнал: Kardiologiia
- Том: 51
- Номер: 11
- Год издания: 2011
- Первая страница: 28
- Последняя страница: 37
- Аннотация: On the basis of earlier executed studies of hypotensive effect of dinitrosyl iron complexes (DNIC) with glutathione, the drug has been created in industrial conditions named oxacom. Preliminary pharmacological studies of oxacom have not revealed negative qualities. The drug has been now tested in 14 healthy men in whom at single intravenous introduction it caused typical response - a decrease of diastolic as well as systolic arterial pressure on 24-27 mmHg through 3-4 min with subsequent very slow restoration in 8-10 hours. The heart rate after initial rise was quickly normalized. Echocardiography revealed unaltered cardiac output in spite of reduced cardiac filling by 28%. The multilateral analysis of clinical and biochemical data has revealed an absence of essential alterations which could lead to pathological consequences. The drug is recommended for carrying out of the second phase of clinical trial. The comparative study of the efficiency of hypotensive action of oxacom, S-nitrosoglutathione (GS-NO) and sodium nitrite (NO2) in rats has shown that the duration of effect was the greatest at oxacom action.
- Добавил в систему: Максимов Георгий Владимирович