Аннотация:Computer data analysis, which is inherent to the inclusive digital economy, is considered one of the crucial components for Industry 4.0. The pivotal role of computer techniques is determined by their universal nature, regardless of the geography of their implementation. Big Data analysis is critical for decision-making support systems to ensure the protection and stability of business continuity in a rapidly evolving economic environment. This chapter discusses technological capabilities to tackle the vital need in Industry 4.0—the personalization of products, services, and decisions. Personalization receives attention due to the increasingly intensive development of various global network communities and collaborations. From a technological perspective, it is crucial to effectively identify homogeneous groupsofnetworkusersandbalancetheneedsanticipatedbyanindividualandgroup. Modern high-precision evidence-based medicine requires computer technology for decision-makingsupportandutilizeswithefficacythecapabilitiesofcomputer-based techniques to differentiate cases of pseudo-progression in human brain tumors. The approach proposed can be expanded to other relevant for Industry 4.0 subject areas.