Visual fear conditioning in mice: Comparison with auditory fear conditioningстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 марта 2017 г.
Аннотация:Up to date, rodent fear conditioning is the most commonly used model of mammalian associative memory in neurobiology. Since the mechanisms of associative memory in this model are mainly studied using auditory fear conditioning, the question about the generality of this mechanisms in respect to other conditioned stimuli remains open. The aim of this work was to compare dynamics of visual and auditory fear memory formation and retrieval. We showed that acquisition of freezing in response to visual conditioned stimulus is significantly slower in comparison with the auditory conditioned stimulus. Moreover, the dynamics of memory retrieval was different in animals, trained to these stimuli, being slower in response to visual conditioned stimulus. This may reflect distinct mechanisms of visual and auditory associative memory consolidation or retrieval in this model. Our results impose constraints on the generality of conclusions about the dynamics associative memory formation obtained solely from classical auditory fear conditioning model in mice.