|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ЦЭМИ РАН |
||
An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activityстатья
- Авторы: Ektova L.V., Goryunova O.V., Eremina V.A., Tikhonova N.I., Medvedeva L.A.
- Журнал: Pharmaceutical Chemistry Journal, (Russian Original REVIEW)
- Том: 53
- Год издания: 2019
- Первая страница: 604
- Последняя страница: 609
- DOI: 10.1007/s11094-019-02046-4
- Аннотация: Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from 5 – 10% to 60 – 63%, decreased the duration of the reaction from 6 h to 2 h, and significantly simplified extraction of products adequate for use at the next stage of photochemical oxidation to furancarbazole derivatives. New data are presented on the cytotoxic activity of the indocarbazole N-glycosides synthesized here, covering a wide range of cell structures and giving a more complete view of the antiproliferative properties of the compounds synthesized
- Добавил в систему: Пугачева Ружена Борисовна