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A mathematical model of in vitro hepatocellular cholesterol and lipoprotein metabolism for hyperlipidemia therapyстатья
- Авторы: Efremov Yuri, Ermolaeva Anastasia, Vladimirov Georgiy, Gordleeva Susanna, Svistunov Andrey, Zaikin Alexey, Timashev Peter
- Журнал: PLoS ONE
- Том: 17
- Номер: 6
- Год издания: 2022
- Издательство: Public Library of Science
- Местоположение издательства: United States
- Первая страница: e0264903
- DOI: 10.1371/journal.pone.0264903
- Аннотация: Cardiovascular diseases associated with high cholesterol (hypercholesterolemia) and low-density lipoproteins (LDL) levels are significant contributors to total mortality in developing and developed countries. Mathematical modeling of LDL metabolism is an important step in the development of drugs for hypercholesterolemia. The aim of this work was to develop and to analyze an integrated mathematical model of cholesterol metabolism in liver cells and its interaction with two types of drugs, statins and PCSK9 inhibitors. The model consisted of 21 ordinary differential equations (ODE) describing cholesterol biosynthesis and lipoprotein endocytosis in liver cells in vitro. The model was tested for its ability to mimic known biochemical effects of familial hypercholesterolemia, statin therapy, and PCSK9 inhibitors. The model qualitatively reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in initial testing of new drugs for cardiology.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | A_mathematical_model_of_in_vitro_hepatocellular_cholesterol… | 7,0 МБ | 3 августа 2022 [TPS_SU] |