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Novel antigens for targeted radioimmunotherapy in hepatocellular carcinomaстатья
- Авторы: Pourhamzeh Mahsa, Asadian Samieh, Mirzaei Hamed, Minaei Azita, Shahriari Elahe, Shpichka Anastasia, Es Hamidreza Aboulkheyr, Timashev Peter, Hassan Moustapha, Vosough Massoud
- Журнал: Molecular and Cellular Biochemistry
- Год издания: 2022
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- DOI: 10.1007/s11010-022-04483-4
- Аннотация: Liver cancer is the sixth common cancer and forth cause of cancer-related death worldwide. Based on usually advanced stages of hepatocellular carcinoma (HCC) at the time of diagnosis, therapeutic options are limited and, in many cases, not effective, and typically result in the tumor recurrence with a poor prognosis. Radioimmunotherapy (RIT) offers a selective internal radiation therapy approach using beta or alpha emitting radionuclides conjugated with tumor-specific monoclonal antibodies (mAbs), or specific selective peptides. When compared to chemotherapy or radiotherapy, radiolabeled mAbs against cancer-associated antigens could provide a high therapeutic and exclusive radiation dose for cancerous cells while decreasing the exposure-induced side effects to healthy tissues. The recent advances in cancer immunotherapy, such as blockade of immune-checkpoint inhibitors (ICIs), has changed the landscape of cancer therapy, and the efficacy of different classes of immunotherapy has been tested in many clinical trials. Taking into account the use of ICIs in the liver tumor microenvironment, combined therapies with different approaches may enhance the outcome in the future clinical studies. With the development of novel immunotherapy treatment options in the recent years, there has been a great deal of information about combining the diverse treatment modalities to boost the effectiveness of immunomodulatory drugs. In this opinion review, we will discuss the recent advancements in RIT. The current status of immunotherapy and internal radiotherapy will be updated, and we will propose novel approaches for the combination of both techniques.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | s11010-022-04483-4_e8eIBaQ.pdf | 1,2 МБ | 3 августа 2022 [TPS_SU] | |
| 2. | Полный текст | s11010-022-04483-4.pdf | 1,2 МБ | 3 августа 2022 [TPS_SU] |