Synthesis of Biogenic Amines by Lactic-Acid Bacteria on Media of Plant and Animal Origin

Shanenko, E.F.; Nikolaev, Y.A.; Serykh, I.N.; Oleskin, A.V.; Mukhamedzhanova, T.G.; Grigorieva, N.V.; El'-Registan, G.I.

Авторы: Shanenko E.F., Nikolaev Yu A., Serykh I.N., Oleskin A.V., Mukhamedzhanova T.G., Grigorieva N.V., El'-Registan G.I.
Журнал: Mikrobiologiia
Том: 91
Номер: 4
Год издания: 2022
Издательство: Izdatel'stva Nauka
Местоположение издательства: Russian Federation
Первая страница: 378
Последняя страница: 394
DOI: 10.1134/S0026261722300208
Аннотация: The intestinal microbiota is known to perform an important role in terms of the host organism’s metabolism and life-sustaining activities. One of the main mechanisms of microbiota—human organism interactivity is based upon biogenic amines (BAs). Therefore, BA synthesis by lactic-acid bacteria (LABs) is extensively researched currently; the BA-forming capacity is considered an essential feature of LAB probiotics.The present work is concerned with BA production by LABs belonging to three species and 13 strains that were isolated from various habitats. They perform diverse ecophysiological functions and were grown on four different media. The media were characterized by different initial BA concentrations. It was established that the LABs can both consume medium-contained BAs and synthesize them de novo during their growth. The data should be taken into account while developing new probiotics. Based on the results of this work, a modified version of BA biosynthesis pathways by LABs was suggested. This work also deals with the implications of the data obtained in terms of the involvement of microbially produced neuroactive compounds in the functioning of the microbial consortium of the human organism and the operation of the nervous and the immune system. Prospects for developing “neurotransmitters-producing biofactories” on the basis of the tested symbiotic and probiotic microorganisms are discussed.
Добавил в систему: Олескин Александр Владимирович

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