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Synthesis, structure and ADMET properties of the monoribbed-functionalized iron(II) clathrochelates with terminal DNA-relevant groupsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 марта 2017 г.
- Авторы: Zelinskii Genrikh E., Belov Alexander S., Vologzhanina Anna V., Pavlov Alexander A., Novikov Valentin V., Varzatskii Oleg A., Voloshin Yan Z.
- Журнал: Inorganica Chimica Acta
- Том: 448
- Год издания: 2016
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 7
- Последняя страница: 15
- DOI: 10.1016/j.ica.2016.04.006
- Аннотация: Monoribbed-functionalized iron(II) cage complexes, designed for the efficient supramolecular binding with nucleic acids, were obtained using nucleophilic substitution of reactive chlorine atom(s) of the mono- and dichloroclathrochelate bis-α-benzildioximate precursors with primary aliphatic amines, having terminal functionalizing groups, as N-nucleophiles. Depending on a reactivity of these nucleophilic agents, the substitutions were performed in various reaction conditions and solvents. The clathrochelates obtained were characterized using elemental analysis, MALDI-TOF mass spectrometry, IR, UV–Vis, 1H and 13C{1H} NMR spectra, and by single-crystal X-ray diffraction experiments (for four of these cage complexes). Fe–N distances in their FeN6-coordination polyhedra fall in the range 1.892(1)–1.954(4) Å and an encapsulated iron(II) ion is slightly shifted from the centers of cage frameworks in the direction of two α-benzildioximate ribbed fragments. The rigidity of the chelate Ndouble bond; length as m-dashC–Cdouble bond; length as m-dashN fragments causes the chelate (bite) N–Fe–N angles α and the heights h of these polyhedra to remain constant; their geometry is intermediate between a trigonal prism (the distortion angle φ = 0°) and a trigonal antiprism (φ = 60°) with the φ values from 25.5° and 28.9°. The conformations of the flexible functionalizing substituents at clathrochelate frameworks are strongly affected by an intramolecular hydrogen bonding.
- Добавил в систему: Новиков Валентин Владимирович