|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ЦЭМИ РАН |
||
Study in vivo of LCS 1269 — derivative of indolocarbazols N-glycosides classтезисы доклада
- Авторы: Golubeva I., Ektova L., Eremina V., Dmitrieva M.
- Сборник: 4th Russian Conference on Medicinal Chemistry with international participants (MedChem Russia 10--14, 2019, Ekaterinburg, Russia)
- Серия: Abstract book (ISBN 978-5-7691-2521-8). Ekaterinburg: Ural Branch of the Russian Academy of Sciences
- Том: 448
- Тезисы
- Год издания: 2019
- Первая страница: 346
- Последняя страница: 346
- Аннотация: Introduction. We studied in vivo the compound LCS 1269, derivative of a indolocarbazols N-glycosides class with cytotoxic and antitumor (a/t) properties [1]. The purpose of the study. Schemes of application and way of LCS 1269 introduction in an organism.Materials and methods. The research was carried out in the experimental dosage form on models of mice solid tumors: cervical cancer CC5. epidermoid carcinoma Lewis Lung (LLC), adenocarcinoma, mammary gland Ca 755, colorectal adenocarcinoma AKATOL, B16 melanoma. Compound was injected intraperitoneally (in/p), subcutaneously (s/c), intravenously (in/v) and inside (per os) to mice in the modes: modes: five times, daily with 24 h interval (5x24h), the 1-st and 5-th days (2 x 96 h), one-time use (one). Animals were watched until their death. Score of a/t effect: inhibition of tumor growth (TGI%), increase in life expectancy (LEI%) of experienced mice relative to the control.The results. LLC – at in/v injection the best a/t effect with TGI 94-51% up to 20 days after the end of treatment was in a dose of 60 mg/kg, mode 5x24h. At s/c injection TGI was=78-58 % up to 20 days, LEI -34 % in a dose of 60 mg/kg, mode 5x24h, in mode 2x96h, a dose of 100 mg/kg, (TGI%=80-68 up to 20 days). At introduction of per os TGI=69-61f % till 8 days in a dose of 150 mg/kg, mode 5x24h. Са 755 – at s/c injection TGI=91-64 % till 20 days, LEI=41% in a dose of 60 mg/kg, mode 5x24h. Cervical cancer CC5 - at in/p injection TGI= 89-58% up to 25 days, in a dose of 60 mg/kg, mode 5x24h. AKATOL - at in /p injection TGI = 89-62% till 25days, in a dose of 60 mg/kg, mode 5x24h. В 16- at in/p injection TGI = 86-68% up to 26 days, LEI = 21%, in 5x24h mode, a dose of 60 mg/kg.Conclusions. LCS 1269 showed a high a/t activity at different ways and modes of injection on mice cultivated solid tumors; in/v and s/c ways of injection were selected, which can be used for further preclinical treatment.
- Добавил в систему: Пугачева Ружена Борисовна