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Influence of the p-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexesстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 апреля 2018 г.
- Авторы: Hanif Muhammad, Meier Samuel, Nazarov Alexey, Risse Julie, Legin Anton, Casini Angela, Jakupec Michael A., Keppler Bernhard K., Hartinger Christian G.
- Журнал: Frontiers in Chemistry
- Том: 1
- Год издания: 2013
- Первая страница: 27
- DOI: 10.3389/fchem.2013.00027
- Аннотация: The synthesis and in vitro cytotoxicity of a series of RuII(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohexylidene-protected carbohydrate is the most cytotoxic with unprecedented IC50 values for the compound class in three human cancer cell lines. This compound shows reactivity to the DNA model nucleobase 9-ethylguanine, but does not alter the secondary structure of plasmid DNA indicating that other biological targets are responsible for its cytotoxic effect.
- Добавил в систему: Назаров Алексей Анатольевич