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Ca2+/recoverin dependent regulation of phosphorylation of the rhodopsin mutant R135L associated with retinitis pigmentosaстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Ivan I Senin, Bosch Laia, Ramon Eva, Zernii Evgeni Yu, Manyosa Joan, Philippov Pavel P., Garriga Pere
- Журнал: Biochemical and Biophysical Research Communications
- Том: 349
- Номер: 1
- Год издания: 2006
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 345
- Последняя страница: 352
- DOI: 10.1016/j.bbrc.2006.08.048
- Аннотация: No single molecular mechanism accounts for the effect of mutations in rhodopsin associated with retinitis pigmentosa. Here we report on the specific effect of a Ca2+/recoverin upon phosphorylation of the autosomal dominant retinitis pigmentosa R135L rhodopsin mutant. This mutant shows specific features like impaired G-protein signaling but enhanced phosphorylation in the shut-off process. We now report that R135L hyperphosphorylation by rhodopsin kinase is less efficiently inhibited by Ca2+/recoverin than wild-type rhodopsin. This suggests an involvement of Ca2+/recoverin into the molecular pathogenic effect of the mutation in retinitis pigmentosa which is the cause of rod photoreceptor cell degeneration. This new proposed role of Ca2+/recoverin may be one of the specific features of the proposed new Type III class or rhodopsin mutations associated with retinitis pigmentosa. (c) 2006 Elsevier Inc. All rights reserved.
- Добавил в систему: Зерний Евгений Юрьевич