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ERP-Correlates of Cognitive Control Violations in Clinical High Risk of Schizophrenia in the Saccadic “Go/NoGo” Paradigmстатья
- Авторы: Slavutskaya M.V., Lebedeva I.S., Omelchenko M.A.
- Журнал: Human Physiology
- Том: 48
- Номер: 4
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 411
- Последняя страница: 420
- DOI: 10.1134/S0362119722040119
- Аннотация: Abstract—Schizophrenia spectrum diseases are characterized by dysfunctions of cognitive control, as well asdisruptions of voluntary saccadic eye movements. The purpose of the study was the analysis of the parametersand topography of N1 and N2 ERP components in the saccadic “Go/NoGo” paradigm as possible markersof cognitive control disruption in patients with clinical high risk (СHR) for schizophrenia. In the group ofpatients, a decrease in the peaks amplitude of the Go- and NoGo-N1 components for stimuli on the right,as well as their latency, regardless of the of the stimulus position, was found, compared with the normal group.The peak latency of the NoGo-N2 to the stimuli on the left was decreased in patients with CHR as comparedto healthy subjects. The N1 and N2 peaks prevailed in the frontal-central EEG leads in CHR schizophreniapatients, and in the parieto-occipital leads in healthy subjects. According to dynamic mapping of the N1component amplitude, in patients with CHR, in contrast to healthy subjects, there was no top-down natureof the focus distribution during potential development. The obtained data suggest that in CHR for schizo-phrenia, there is a disruption of cognitive regulation, including the processes of spatial attention and stimulusevaluation (N1), as well as monitoring of inhibition and memory update (N2).Keywords: saccade, “Go/NoGo” paradigm, CHR for schizophrenia, evoked potentials, cognitive control
- Добавил в систему: Славуцкая Мария Валерьевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | HP411-4.2022.pdf | HP411-4.2022.pdf | 717,6 КБ | 13 сентября 2022 [SlavutskayaMV] |