Effects of Blockade of Cholinesterase on Negative Disorders in Schizophrenia

Morozova, M.A.; Potanin, S.S.; Rupchev, G.E.; Burminskiy, D.S.; Lepilkina, T.A.; Beniashvili, A.G.

Авторы: Morozova M.A., Potanin S.S., Rupchev G.E., Burminskiy D.S., Lepilkina T.A., Beniashvili A.G.
Журнал: Neuroscience and Behavioral Physiology
Том: 52
Номер: 5
Год издания: 2022
Издательство: Kluwer Academic/Plenum Publishers
Местоположение издательства: United States
DOI: 10.1007/s11055-022-01284-6
Аннотация: Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 121, No. 8, Iss. 1, pp. 37–44,August, 2021. Original article submitted February 17, 2021. Accepted February 23, 2021.Objective. To assess the possible infl uence of blockade of cholinesterase on negative disorders in schizophrenia patients. Materials and methods. The study included 26 patients (including 13 women) with paranoid schizophrenia, episodic-progressive form (ICD-10), in remission and receiving stable antipsychotictherapy. Mean age was 40.4 (SD 11.7) years. The following psychometric scales were used: the Positive andNegative Syndrome Scale (PANSS), the Global Assessment of Functioning Scale (GAF), a neurocognitivemethod (the Brief Assessment of Cognition in Schizophrenia, BACS), and projective psychological methods (Rorschach test). Results and conclusions. These studies showed that augmentation of maintenanceantipsychotic therapy with a cholinesterase blocker was found to be an effective means of infl uencingnegative disorders, particularly decreasing the extent of symptoms of emotional defi cit. Improvements incognitive functioning on the BACS occurred independently of changes in the severity of negative disorderson the PANSS. The Rorschach test demonstrated improvements in conventional orientation of thinking inthe patients. There were no cases with exacerbation of psychotic symptoms.Keywords: schizophrenia, negative disorders, cognitive dysfunction, therapy, cholinesterase blocker.
Добавил в систему: Рупчев Георгий Евгеньевич

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