Lyophilization with Subsequent Derivatization vs Microextraction by Packed Sorbent (MEPS) in the Analysis of Exhaled Breath Condensate by Gas Chromatography–Mass Spectrometry

Авторы: Revelsky A.I., Kozyr’ A.S., Samokhin A.S., Anaev E.Kh, Revelsky I.A.
Журнал: Journal of Analytical Chemistry
Том: 77
Номер: 10
Год издания: 2022
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 1294
Последняя страница: 1299
DOI: 10.1134/S1061934822100136
Аннотация: We compared two approaches to the sample preparation of exhaled breath condensate (EBC) samplesfrom healthy volunteers for the detection of traces of low-molecular-weight organic compounds by gaschromatography–mass spectrometry: lyophilization followed by derivatization and microextraction bypacked sorbent (MEPS). Several fatty, hydroxy-, and dicarboxylic acids and urea were detected as silyl derivatives;decanal was also found in the samples. Alanine, glycine, valine, proline, and isoleucine were recordedas isobutoxycarbonyl ethers. MEPS preconcentration on silica with attached octadecyl groups as an adsorbentensures the detection of some fatty acids, alkanes, alcohols, amines, and decanal in the EBC samples.The approaches to sample preparation used to detect traces of unknown low-molecular-weight organic compoundsin EBC confirm and complement each other.
Добавил в систему: Ревельский Александр Игоревич

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