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Expression of pp60 c-src in human small cell and non-small cell lung carcinomas.PMID: 1375484статья
- Авторы: Mazurenko NN, Kogan EA, Zborovskaya IB, Kisseljov FL
- Журнал: European Journal of Cancer
- Том: 28
- Номер: 2-3
- Год издания: 1992
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 372
- Последняя страница: 377
- Аннотация: c-src protein was found in 60% of lung carcinomas (20 of 33 cases or primary tumours) by immunoblotting with a monoclonal antibody (Mab 327) and immunohistochemistry with serum from rabbits bearing tumours induced by Rous sarcoma virus. src protein expression was assessed in 4 small cell lung carcinomas and in an atypical carcinoid of neuroendocrine origin. However, pp60c-src was also found in non-small cell lung carcinomas: in 60-80% of adenocarcinomas and bronchiolo-alveolar cancers and in 50% of squamous cell carcinomas. In the squamous cell carcinomas, src protein was expressed more frequently in poorly differentiated than in well and moderately differentiated carcinomas. Expression of pp60c-src was not found in epithelial cells of histologically unchanged lung tissues. These results show that pp60c-src may be activated in human lung carcinomas of different histopathological types.
- Добавил в систему: Мазуренко Наталья Николаевна