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Instability of chromosome 6 microsatellite repeats in human cervical tumors carrying papillomavirus sequencesстатья
- Авторы: Kisseljov F., Semionova L., Samoylova E., Mazurenko N., Komissarova E., Zourbitskaya V., Gritzko T., Kozachenko V., Netchushkin M., Petrov S., Smirnov A., Alonso A.
- Журнал: International Journal of Cancer
- Том: 69
- Номер: 6
- Год издания: 1996
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- Первая страница: 484
- Последняя страница: 487
- Аннотация: Loss of heterozygosity (LOH) in chromosome 6 in human squamous cervical carcinomas was analyzed in the long and short arms of the chromosome using 3 pairs of primers each. In all cases, normal adjacent tissue was used as control. Among 51 cases analyzed, we identified LOH or microsatellite instability in 23% using primer D6S291 (located at position 6p21.3) and in 11% using primers D6S308 (6q16.3-6q27) and D6S270 (6q22.3-6q23.2). On the contrary, no significant LOH or genomic instabilities were detected with primers D6S306 (6p22.3-6p21.2), D6S299 (6p22.3-6p21.3) and D6S287 (6q21-6q23.3). Our results thus suggest the existence of instable loci at 3 regions of chromosome 6. Whether these loci contain putative tumor-suppressor genes or genes involved in cell cycle control remains unknown.
- Добавил в систему: Мазуренко Наталья Николаевна