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Brain Metabolite, Myo-inositol, Inhibits Catalase Activity: A Mechanism of the Distortion of the Antioxidant Defense System in Alzheimer’s diseaseстатья
- Авторы: Ali F., Manzoor U., Bhattacharya R., Bansal A.K., Chandrashekharaiah K.S., Singh L.R., Saraswati S.M., Uversky V., Dar T.A.
- Журнал: ACS Omega
- Том: 7
- Номер: 15
- Год издания: 2022
- Первая страница: 12690
- Последняя страница: 12700
- DOI: 10.1021/acsomega.1c06990
- Аннотация: levels, leading to decreased cell viability. Furthermore, MI induces distortion of the active heme center with an overall loss of structure and stability of catalase. MI also alters distances of the vital active site and substrate channel residues of catalase. The present study provides evidence for the involvement of MI in the inactivation of the antioxidant defense system during oxidative stress-induced pathogenesis of AD. Regulation of MI levels, during early presymptomatic stages of AD, might serve as a potential early-on therapeutic strategy for this disease.
- Добавил в систему: Уверский Владимир Николаевич