Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 24 марта 2017 г.
Аннотация:The toxicity of ferrocenylethyl benzotriazole and other ferrocene compounds including ferrocenylmethyl benzimidazoles, ferricenium salts and ferrocenylmethyl adenine, was studied. All ferrocene complexes under investigation
showed low or medium toxicities. On the basis of an earlier model of chemical carcinogenesis, the antitumor activity of
ferrocenylalkyl azoles and ferricenium salts was studied in vivo in the so-called subcapsular test on human tumors.
This effectiveness was compared with that of cisplatin. A series of ferrocenylalkyl azoles were synthesized by interacting azoles either with α-hydroxyalkyl ferrocenes FcC(OH)R1R2 in organic solvent in the presence of aqueous HBF4 in quantitative yields or with trimethyl(aminomethyl)ferrocene iodide in an aqueous-basic medium in good yields. The X-ray determinations of molecular and crystal structures of α-(1-benzotriazolyl)ethylferrocene and α-(1-naphthatriazolyl)ethylferrocene were performed.