Adrenergic and rate control of excitation pattern in rat caval veins cardiac tissueстатьяТезисы
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 14 августа 2017 г.
Аннотация:Objectives: Thoracic veins in most mammals possess by myocardial tissue. Bioelectrical properties of pulmonary
veins myocardium are well described and since considered to be responsible for the onset of supraventricular
arrhythmia. Nevertheless, excitation pattern of cardiac tissue in caval veins remains poor investigated. The present
study is aimed to characterize the excitation pattern in rat caval veins myocardium under basal condition and
adrenergic stimulation.
Methods: Multicellular preparations of left atrium (LA), right (RAV) and left anterior (LAV), posterior caval
(PAV) and azygos veins (AzV) were dissected from male rats (200–250 g) and perfused at 37 °C with Tyrode
solution. Excitation was mapped in electrically paced preparations treated with potentially sensitive dye di-4-
ANEPPS (5 μM) and blebbistatin (1 μM) with use of CCD camera (WuTech Instruments). Conduction velocity
(CV) was assessed with aid of RedShirtImaging software in control or after administration of isoproterenol
(1 lM, ISO) or phenylephrine (10 lM, Phe).
Results: At basal conditions, all preparations of caval veins, excepting PAV, demonstrated excitability, atrial-like
action potentials (AP), uniform conduction and similar CV. In LA, RAV, LAV and AzV, averaged CV was
8415, 8012, 7614 and 6616 cm/c respectively. ISO weakly affected conduction in caval veins. Phe administration
resulted in significant reduction of CV, conduction blocks and initiation of temporal AP alternans in
caval veins; similar effects were observed at rapid pacing.
Conclusion: Rat atrial and caval veins myocardium demonstrates similar bioelectrical properties and excitation
pattern at basal condition. Adrenergic stimulation or rapid pacing induces conduction disturbances in rat caval
veins cardiac tissue.