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Synthesis, structure and redox potentials of biologically active ferrocenylalkyl azolesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 марта 2017 г.
- Авторы: Snegur L.V., Simenel A.A., Nekrasov Yu S., Morozova Elena A., Starikova Zoya A., Peregudova Svetlana M., Kuzmenko Yuliya V., Babin Valery N., Ostrovskaya Larissa A., Bluchterova Natalia V., Fomina Margarita M.
- Журнал: Journal of Organometallic Chemistry
- Том: 689
- Год издания: 2004
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 2473
- Последняя страница: 2479
- Аннотация: The syntheses, structures, electrochemical properties of the series of ferrocenylalkyl azoles, FcAlkAz, as well as the antitumor activity of ferrocenylmethyl benzimidazole have been studied. Above mentioned compounds were investigated by the method of cyclic voltametry. All of them exhibited a reversible one-electron oxidation–reduction wave owing to the ferrocene–ferrocenium redox couple with a positive shift (0.50–0.65 V) compared with that of ferrocene (0.42 V). The X-ray determination of molecular structures of 1-(ferrocenylmethyl)imidazole, 1-(ferrocenylbenzyl)imidazole and 1-(ferrocenylmethyl)bezimidazole was carried out. Compound with imidazolyl substituent was found to be present in N-protonated form. Antitumor activity of 1-(ferrocenylmethyl)benzimidazole against some solid tumor models such as adenocarcinoma 755 (Ca755), melanoma B16 (B16) and Lewis lung carcinoma was studied. The antitumor activity of compound was compared with cisplatin effectiveness against some experimental tumor systems.
- Добавил в систему: Сименел Александр Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2473.pdf | 353,7 КБ | 21 марта 2017 [alexsim] |