Место издания:АННМО "Вопросы онкологии" Санкт-Петербург
Первая страница:355
Последняя страница:355
Аннотация:The histological unit, which is the site of B2cell concentration, is the lymphoid follicle. These cells make up the vast majority of circulating B lymphocytes. B2 cells undergo selection in the bone marrow and are involved in the formation of an adaptive humoral immune response to thymus-dependent antigens. Thus in patients with gastric cancer an interruption of the immunological repertoire of B2 cells was established: the presence of a pronounced proportion of CD21+ B cells with weak expression, a significant number of CD23+ cells, cases of clonal B cells. In most of the studied samples, B cells were polyclonal with a predominance of Ig-κ. When implementing the thymus-dependent pathway of the immune response in such patients, there will be an interruption of antibody production and weakening of antitumor immunity.