Cathepsin K in Pathological Conditions and New Therapeutic and Diagnostic Perspectives

Mijanović, O.; Jakovleva, A.; Branković, A.; Zdravkova, K.; Pualic, M.; Belozerskaya, T.A.; Nikitkina, A.I.; Parodi, A.; Zamyatnin, A.A.

Авторы: Mijanović Olja, Jakovleva Aleksandra, Branković Ana, Zdravkova Kristina, Pualic Milena, Belozerskaya Tatiana A., Nikitkina Angelina I., Parodi Alessandro, Zamyatnin Andrey A.
Журнал: International Journal of Molecular Sciences
Том: 23
Номер: 22
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 13762
DOI: 10.3390/ijms232213762
Аннотация: Cathepsin K (CatK) is a part of the family of cysteine proteases involved in many important processes, including the degradation activity of collagen 1 and elastin in bone resorption. Changes in levels of CatK are associated with various pathological conditions, primarily related to bone and cartilage degradation, such as pycnodysostosis (associated with CatK deficiency), osteoporosis, and osteoarthritis (associated with CatK overexpression). Recently, the increased secretion of CatK is being highly correlated to vascular inflammation, hypersensitivity pneumonitis, Wegener granulomatosis, berylliosis, tuberculosis, as well as with tumor progression. Due to the wide spectrum of diseases in which CatK is involved, the design and validation of active site-specific inhibitors has been a subject of keen interest in pharmaceutical companies in recent decades. In this review, we summarized the molecular background of CatK and its involvement in various diseases, as well as its clinical significance for diagnosis and therapy.
Добавил в систему: Замятнин Андрей Александрович

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Cathepsin K in Pathological Conditions and New Therapeutic and Diagnostic Perspectivesстатья

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