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Efficacy of Ficus tikoua Bur. extract in ethylene glycol-induced urolithiasis model in SD ratsстатья Электронная публикация
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Bervinova Arina V., Palikov Viktor A., Mikhailov Evgeny S., Palikova Yulia A., Borozdina Natalya A., Kazakov Vitaly A., Rudenko Pavel A., Tukhovskaya Elena A., Dyachenko Igor A., Slashcheva Gulsara A., Goryacheva Natalya A., Sadovnikova Elena S., Kravchenko Irina N., Kalabina Elena A., Shinelev Maksim V., Wu Peng, Murashev Arkady N.
- Журнал: Frontiers in pharmacology
- Том: 13
- Год издания: 2022
- Издательство: Frontiers Media]
- Местоположение издательства: [Lausanne, Switzerland
- Номер статьи: 974947
- DOI: 10.3389/fphar.2022.974947
- Аннотация: The development of new herbal preparations for the treatment of urolithiasis is an urgent task of medical science. Ficus have attracted the attention of pharmacologists due to a wide range of biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied the effectiveness of Bur. in SD rats in which urolithiasis was induced by 6 weeks of oral administration of ethylene glycol 0.5% instead of drinking water. Administration of the extract of Bur., as well as comparative drug Cystone after modeling of urolithiasis lead to the restoration of diuresis and the concentration of inorganic phosphates starting from the 6th week of the experiment. The use of the Bur. extract for 6 weeks, both during the modeling of urolithiasis and during the recovery period, led to the restoration of the percentage of lymphocytes in the blood, content of sodium, chlorine and inorganic phosphates in the blood to the control level. Thus, the extract of Bur. seems to be a promising drug for effective treatment of the initial stages of the development of urolithiasis.
- Добавил в систему: Калабина Елена Андреевна