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Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoatesстатья
- Авторы: Lipaikin S.Y., Yaremenko I.A., Terent’ev A.O., Volova T.G., Shishatskaya E.I.
- Журнал: Advances in Polymer Technology
- Том: 2022
- Год издания: 2022
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- DOI: 10.1155/2022/6353909
- Аннотация: In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems. © 2022 Sergei Y. Lipaikin et al.
- Добавил в систему: Малошицкая Ольга Александровна