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Hidden Reactivity of Barbituric and Meldrum’s Acids: Atom-Efficient Free-Radical C-O Coupling with N -Hydroxy Compoundsстатья
- Авторы: Krylov I.B., Paveliev S.A., Budnikov A.S., Segida O.O., Merkulova V.M., Vil’ V.A., Nikishin G.I., Terent’ev A.O.
- Журнал: SYNTHESIS-STUTTGART
- Том: 54
- Номер: 2
- Год издания: 2022
- Издательство: Georg Thieme Verlag
- Местоположение издательства: Germany
- Первая страница: 506
- Последняя страница: 516
- DOI: 10.1055/a-1643-7642
- Аннотация: The reactivity of CH-acidic and structurally related enolcontaining heterocycles towards N-oxyl radicals is disclosed. Traditionally, these substrates have been considered as reactants for ionic transformations. Highly selective and efficient N-oxyl radical mediated C-O coupling of substituted barbituric or Meldrum’s acids with N-hydroxy compounds (N-hydroxyimides, hydroxamic acids, oximes, and N-hydroxybenzotriazole) was achieved using inexpensive manganese-containing salts as oxidants. Metal-free C-O coupling was demonstrated using diacetyliminoxyl as both the oxidant (hydrogen-atom acceptor) and the coupling partner. © 2021. Thieme. All rights reserved.
- Добавил в систему: Малошицкая Ольга Александровна