MICROSPHERICAL POLYSTYRENE-DIVINYLBENZENE PARTICLES HYBRIDIZED WITH EREMOMYCIN STABILIZED GOLD NANOPARTICLES AS A STATIONARY PHASE

Prosuntsova, D.S.; Ananieva, I.A.; Nesterenko, P.N.; Shpigun, O.A.

Авторы: Prosuntsova Darya S., Ananieva Irina A., Nesterenko Pavel N., Shpigun Oleg A.
Журнал: Заводская лаборатория. Диагностика материалов
Том: 88
Номер: 12
Год издания: 2022
Издательство: ТЕСТ-ЗЛ
Местоположение издательства: М.
Первая страница: 14
Последняя страница: 20
DOI: 10.26896/1028-6861-2022-88-12-14-20
Аннотация: A novel enantioselective adsorbent was obtained by hybridization of microspherical polysty- rene-divinylbenzene (PS-DVB) macroporous particles with eremomycin-stabilized gold nano- particles (GNPs). Macrocyclic antibiotic eremomycin was used as a stabilization agent to ob- tain GNPs which were then characterized by transmission electron microscope. The average diameter of obtained nanoparticles is about 16.6 nm. Eremomycin-stabilized nanoparticles were successfully embedded into the porous polymer structure with a resulting chiral selector content of 37.5 ìmol/g. The obtained PS-DVB composite containing GNPs with immobilized eremomycin was studied by scanning electron microscopy and diffuse reflectance spectroscopy. The values of the specific surface area (500 m2/g) and porosity of the adsorbent (0.39 cm3/g) are measured using nitrogen adsorption at low temperatures. The obtained composite material was used as a chiral stationary phase of liquid chromatography. A good separation enantio- selectivity to amino acids, their derivatives and beta-blockers under RPC (reversed-phase) and HILIC (Hidrophilic Interaction Liquid Chromatography) mode is demonstrated. The results obtained revealed that the prepared Eremo@GNP@PS-DVB composite is promising for use as a stationary phase in HPLC.
Добавил в систему: Ананьева Ирина Алексеевна

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MICROSPHERICAL POLYSTYRENE-DIVINYLBENZENE PARTICLES HYBRIDIZED WITH EREMOMYCIN STABILIZED GOLD NANOPARTICLES AS A STATIONARY PHASEстатья

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